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Synonyms :
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IL-17, CTLA-8
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Description :
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The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains. Manufactured using all non-animal reagents.
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Catalog #:
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AF-200-17
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Biological Activity :
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Assay #1: Determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.
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AA Sequence :
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MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
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PubMed Link :
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Human IL-17A
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Country of Origin :
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USA
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Size B |
25µg |
£145 |
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Size C |
1mg |
£1760 |
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Special
Sizes:
Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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